AC133 hematopoietic stem cell antigen: human homologue of mouse kidney prominin or distinct member of a novel protein family?
نویسندگان
چکیده
1. Scaradavou A, Woo B, Woloski BMR, Cunningham-Rundles S, Ettinger LJ, Aledort LM, Bussel JB: Intravenous anti-D treatment of immune thrombocytopenic purpura: Experience in 272 patients. Blood 89:2689, 1997 2. Salama A, Kiefel V, Amberg R, Mueller-Eckhardt C: Treatment of autoimmune thrombocytopenic purpura with Rhesus antibodies (antiD). Blut 49:29, 1984 3. Nance SJ, Arndt P, Garratty G: Predicting the clinical significance of red cell alloantibodies using a monocyte monlayer assay. Transfusion 27:449, 1987
منابع مشابه
Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins.
Prominin/CD133 is a 115/120-kDa integral membrane glycoprotein specifically associated with plasma membrane protrusions in epithelial and non-epithelial cells including neuroepithelial and hematopoietic stem cells. Here we report the identification as well as molecular and cell biological characterization of mouse, rat, and human prominin-2, a 112-kDa glycoprotein structurally related to promin...
متن کاملCharacterization of Prominin-2, a New Member of the Prominin Family of Pentaspan Membrane Glycoproteins*□S
Prominin/CD133 is a 115/120-kDa integral membrane glycoprotein specifically associated with plasma membrane protrusions in epithelial and non-epithelial cells including neuroepithelial and hematopoietic stem cells. Here we report the identification as well as molecular and cell biological characterization of mouse, rat, and human prominin-2, a 112-kDa glycoprotein structurally related to promin...
متن کاملProminin: a story of cholesterol, plasma membrane protrusions and human pathology.
Prominin is the first identified member of a novel family of polytopic membrane proteins conserved throughout the animal kingdom. It has an unusual membrane topology, containing five transmembrane domains and two large glycosylated extracellular loops. In mammals, prominin is expressed in various embryonic and adult epithelial cells, as well as in nonepithelial cells, such as hematopoietic stem...
متن کاملMonoclonal Antibodies 13A4 and AC133 Do Not Recognize the Canine Ortholog of Mouse and Human Stem Cell Antigen Prominin-1 (CD133)
The pentaspan membrane glycoprotein prominin-1 (CD133) is widely used in medicine as a cell surface marker of stem and cancer stem cells. It has opened new avenues in stem cell-based regenerative therapy and oncology. This molecule is largely used with human samples or the mouse model, and consequently most biological tools including antibodies are directed against human and murine prominin-1. ...
متن کاملRat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein.
Mouse prominin is the first characterized member of a novel family of membrane glycoproteins. It displays a characteristic membrane topology with five transmembrane segments and two large glycosylated extracellular loops. Prominin orthologues and paralogues have been identified in human, fish, fly, and worm. Recently, a cDNA sequence encoding the rat homologue of mouse prominin has been reporte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Blood
دوره 91 7 شماره
صفحات -
تاریخ انتشار 1998